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The mechanisms involved in GABA release were first investigated in beta cell lines, where GABA secretion was shown to be dependent on the presence of extracellular Ca 2+ [105], suggesting that GABA is released in response to an increase in cytosolic Ca 2+ levels

O.MagalhaesJ

The PC-Cd complexes are up to 1000 times less toxic to many enzymatic proteins than the free Cd ions (Solt et al., 2003)

doi: 10.1038/s41392-021-00831-w

Free radicals can damage melanocyte stem cells, thus reducing the number of melanocytes at the hair bulb This event is an example of a first-stage failure point, and it leads to melanocyte stem cell dysfunction (Jo et al., 2018)