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Acknowledgements This work was supported by National Natural Science Foundation of China (82170873, 82371424), and Tsinghua University Spring Breeze Fund (20211080005)

While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

Much like if you were to procrastinate and become swamped with homework, youre suddenly overwhelmed and may not perform your best on the task at hand

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