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The activation of IER3 in the mucosa downregulates Nrf2 through the PI3K/Akt pathway, leading to decreased ROS production and apoptosis in a colitis model, which keeps Nrf2 levels low in IBD (94)

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The anti-diabetic drugs glitazones which improves mitochondrial functions (such as activities of cI and cIV) and biogenesis (NINDS Exploratory Trials in Parkinson Disease (NET-PD) FS-ZONE Investigators, 2015)