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Because of the brains need for oxygen, keeping oxidative stress at bay is an uphill battle

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Results Age-related increased oxidative load in LECs was linked to progressive decline in Nrf2, Cat and Prdx6 expression To identify age-related changes in ROS production and the connection between expression of Prdx6 and its regulator Nrf2, an antioxidant defense pathway, we monitored the intracellular redox-state of primary hLECs of different ages cultured in 96 well plate by using H2-DCF-DA dye 8,43

Taken together, these findings suggest the APB receptor on ON-bipolar cells is mGluR6