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First described by Lee and Cohen at USC in 2015

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Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg

investigated the effects of cholestasis and lipopolysaccharide (LPS)-induced inflammation in mice, noting a decrease in Slc25a39 mRNA in the liver under cholestatic conditions, along with decreased Slc25a39/40 mRNA and protein levels in the kidneys

Oral administration involves the peptide passing through the digestive system, which can diminish its potency due to enzymatic breakdown