Affecting approximately 1 in 100,000 to 160,000 individuals, BBS presents as a clinically heterogeneous array of symptoms including obesity, learning impairments, retinal dystrophy, and kidney dysfunction (2)
98 Hence, preclinical research suggests that DPP4 inhibition may ameliorate T1DM through pathways involving both incretin-based mechanisms and anti-inflammatory effects
Evidence has shown that the interplay between ferroptosis and trophoblast dysfunction, dysregulation of the immune system, and placental oxidative damage disrupts the delicate balance crucial for the success of a pregnancy
doi: 10.1007/s00018-017-2609-7 172 DrgoiCMNicolaeAC
It's important to note that gastrointestinal side effects are often dose-dependent and may be managed through appropriate dose titration under healthcare provider supervision