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Nitric oxide in plants: the roles of ascorbate and hemoglobin

These reactions were dose-dependent, with higher doses producing more frequent and sometimes more pronounced reactions

Animal LD50 studies showed toxic levels around 320 mg/kg body weight, translating to approximately 22,400 mg for a 70 kg human

Ongoing clinical access throughout treatment

Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)