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Tumor microenvironment-induced structure changing drug/gene delivery system for overcoming delivery -associated challenges

In the SURMOUNT-1 study, a phase 3 clinical trial in obese patients, randomized participants in a 1:1:1:1 ratio to tirzepatide (5, 10, 15 mg) or placebo over 72 weeks, significant weight reductions were observed at 72 weeks: 15.0% for 5 mg, 19.5% for 10 mg, 20.9% for 15 mg, compared to 3.1% for placebo [18]

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Direct protein: protein interactions between the C-terminal of JNK and GST were reported with a binding constant of approximately 200 nm (Wang et al ., 2001)

If tolerated, this is the standard maintenance dose for most women