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98 By recognizing the molecular hallmarksNF-B and ROS activity in inflammation, SMAD-mediated gene expression in fibroblastic proliferation, and MMPTIMP equilibrium during remodelingclinicians can tailor modalities to support tissue progression at every step

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Clinical trials would need to assess both hemodynamic parameters and clinical outcomes including walking distance, pain scores, and amputation rates to establish therapeutic benefit

Chen H, Islam W, El Halabi J et al (2025a) Innovative gastrointestinal drug delivery systems: nanoparticles, hydrogels, and microgrippers

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