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Folic acid is synthetic, does not exist in nature, and must be converted through DHFRan enzyme that is extremely slow and variable in humansbefore your body can use it. It accumulates in blood as unmetabolized folic acid (UMFA), blocks folate receptors, and competes with active forms

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Particularly for women, the gut microbiota (GM) and the microbiota of the reproductive tractincluding both the upper and lower sectionsare crucial in regulating reproductive health

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O'Regan RM, Cisneros A, England GM, MacGregor JI, Muenzner HD, Assikis VJ, Bilimoria MM, Piette M, Dragan YP, Pitot HC, Chatterton R, Jordan VC: Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth