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Randomized trials have shown that liraglutide and semaglutide can improve walking distance in people with PAD, while observational studies have linked semaglutide and tirzepatide to lower risks of amputation, lower-extremity revascularization, and mortality

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Private prescribing is possible but requires careful clinical oversight given its contraindication profile

"In patients with obesity who were prescribed semaglutide or liraglutide, we found that long-term weight reduction varied significantly based on the medication's active agent, treatment indication, dosage and persistence with the medication," said Hamlet Gasoyan, lead author of the study, in a statement

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