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In clinical trials, tirzepatide produces more weight loss (20-22% at max dose) compared to orforglipron (12.4% at max dose)
GLP-1R activation by retatrutide promotes glucose-dependent insulin secretion, suppresses glucagon during hyperglycemia, delays gastric emptying, and reduces appetite via CNS signaling
By dilating blood vessels, it improves circulation, which can help with erectile dysfunction and boost sexual performance
Candidates for Semaglutide have a BMI over 30, or over 27 with at least one related condition such as high blood pressure, high cholesterol or diabetes (Type 2)
Self-administration means you control timing and technique
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