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A later phase 3b trial of the higher 7.2 mg dose, STEP UP, reported mean bodyweight change of 18.7% at 72 weeks versus 15.6% at 2.4 mg and 3.9% with placebo

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Second, the nested casecontrol design with propensity matching enabled efficient evaluation of multiple relatively uncommon outcomes while strengthening internal validity and supporting a clear temporal relationship between GLP-1RA exposure and SUD diagnoses

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Under optimal conditions, the body can produce this important peptide itself