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If the individual has significant accumulation (older age, chronic disease, prior chemotherapy), the first course may produce the most noticeable effects Subsequent courses: Target newly accumulated senescent cells

Most participants were female (236 (77.6%)) and white (283 (93.1%)), with a mean (s.d.) age of 47.3 (11.0) years, body mass index of 38.5 (6.9) kg m 2 and weight of 106.0 (22.0) kg

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