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While the semaglutide CVOTs did not show an increased incidence of hospitalization for HF compared to placebo (101), in earlier smaller studies with liraglutide in patients with HF with reduced left ventricular ejection fraction, the GLP-1RA was associated with increased incidence of serious cardiac events (rhythm disorders, worsening of HF) (102, 103)

While these findings have not yet been confirmed in humans, they highlight an important gap in current research

This synthetic peptide (exendin-4 analog) retained the beneficial properties of the natural peptide while being manufactured for clinical use

Electrophysiologic testing and imaging techniques are not as helpful as we would like them to be for making a diagnosis

Nicotine aversion: neurobiological mechanisms and relevance to tobacco dependence vulnerability