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Retatrutide shows a higher absolute weight loss percentage in recent phase 3 trials than tirzepatide achieved in its foundational trials

After the membrane was blocked with 5% skim milk TBST (20 mM Tris-Cl (pH 7.4), 150 mM NaCl, 0.1% Tween-20), it was incubated with streptavidin (SA) coupled to horseradish peroxidase (HRP) (1:1000, Pierce) and washed three times with TBST for 10 min

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Biogerontology 23(5):641652

Future clinical studies should determine which patient groups should be targeted as potential candidates for the symptomatic and/or neuroprotective effects of GLP-1RAs, to find out, whether combinations of GLP-1RA with other classes of drugs can further enhance their effectiveness, and evaluate their long-term effect on the course of the disease and side effects