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It is listed as a rare adverse reaction in UK product information for both oral and injectable B12 preparations, and most people tolerate B12 supplements well even at high doses
[DOI] [PubMed] [Google Scholar] 193.Jimi E, Aoki K, Saito H, DAcquisto F, May MJ, Nakamura I, et al
Positive results from the Phase II WILLOW study and Phase III ASPEN study demonstrate that compared to placebo controls, DPP1 inhibition treatment can significantly extend time intervals to first acute exacerbations in bronchiectasis patients and effectively reduce overall acute exacerbation occurrence frequency ( From clinical safety analysis perspectives, DPP1 inhibitors demonstrate generally favorable overall safety characteristics
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