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Clinicians overseeing trial participants assessed each individual's response and tolerability before proceeding to the next dose level

[DOI] [PMC free article] [PubMed] [Google Scholar] 324.Han S.H., Safeek R., Ockerman K., Trieu N., Mars P., Klenke A., Furnas H., Sorice-Virk S

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The quality of the selected RCTs was assessed by same authors independently using the Cochrane Collaboration risk of bias tool based on the following criteria: "allocation concealment, randomization generation, outcome assessors and blinding of participants, selective outcome reporting, incomplete outcome data, and other sources of bias"

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