122 Two PCOS mouse models were developed using prenatal androgenization (via DHT administration to pregnant dams on gestational days 1618) and postweaning androgenization (via subcutaneous DHT implants at day 21), followed by high-fat diet exposure and 28-day treatment with GLP-1-based mono- and multi-agonists or metformin starting on postnatal day 80, with outcomes assessed at day 108
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The Potential of Retatrutide Retatrutide leads to 24.2% mean WL at the highest dose after 48 weeks in people with obesity, with no evidence of plateau and up to 26% of participants achieving 30% WL - approaching the efficacy Roux-en-y gastric bypass, one of the most effective BS procedures
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doi: 10.1210/jc.2015-4180 22 UstulinMParkSYChoiHChonSWooJTRheeSY