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These reactions are usually temporary and subside within a few hours

J Nutr Biochem 60:4760 Srinivasan MP et al (2021) Differential cytotoxicity, ER/oxidative stress, dysregulated AMPK signaling, and mitochondrial stress by ethanol and its metabolites in human pancreatic acinar cells

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EGFR [11], integrins [74,75,76], GPCR signaling components [77], InsR-A [78]) contribute to the complexity (and failure) that has plagued IGF-1R targeted drug development, but also offer more possibilities for co-targeting strategies

By elevating oxidative stress, NRF2 degradation induces apoptosis in cancer cells and increases their sensitivity to chemotherapeutic agents, thereby enhancing the effectiveness of chemotherapy [95]