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Mechanical and chemical stress can lead to an increase in the production of oxygen free radicals, resulting in oxidative damage to tissue (Pizzino et al., 2017)

At the end of one year, six of the 14 patients receiving melatonin were still living, compared to one of the 16 undergoing radiotherapy alone

periportal hepatocytes may contain nearly twice the centrilobular concentration, enterocytes at the villus tip have a higher content than the crypts, and renal proximal tubular cells have more GSH than other parts of the nephron (56)

This mutation changed a Leu at position 34 to a Phe (L34F) and resulted in deficiency of CART peptide in the blood