Dizziness may occur, particularly if rapid weight loss leads to postural hypotension or if patients are concurrently taking antihypertensive medications that require dose adjustment
In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms
The knee-replacement consent was torn up, her CPAP sat unplugged, and her blood pressure rivaled her college-athlete days
97 In a trial in 60 college students, 350 mg of a full-spectrum ashwagandha extract twice daily for 30 days was more effective than placebo at improving self-reported sleep quality and reducing food cravings, but not for reducing self-perceived stress levels
A weak association exists between upper gastrointestinal symptoms and the rate of gastric emptying
