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These binuclear copper ions are connected to six histidine residues (His 61 , His 85 , His 94 , His 259 , His 263 , and His 296 residues), which further interact with the adjacent residues, viz

(cymbiotika.com) Unlike many other antioxidants that you must get solely from your diet, your body can manufacture its own glutathione

Thus, phase I reactions are usually oxidation, reduction, dealkylation, epoxidation, oxidative deamination reactions, etc., which are primarily catalyzed by enzymes of the cytochrome P450 (P450