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Joints requiring a large surface area of cartilage restoration are challenging for a number of reasons, including mechanical demands, graft fixation, and the large number of cells required for transplantation (in cell based therapies)

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Common symptoms of a gluten allergy include diarrhea, bloating, headaches, canker sores, fatigue, irregular menstrual cycles in women, joint pain, and sleep problems

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Reducing frequency temporarily or applying a light, non-comedogenic moisturizer can help minimize irritation during the adjustment period