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A key feature is ECM degradation, which results from the upregulation of MMPs and ADAMTSs, leading to the breakdown of proteoglycans and collagen, ultimately causing structural damage to the intervertebral disc (36,37)

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[1] The gastrointestinal effects of Zepboundincluding nausea, reduced appetite, early satiety, and delayed gastric emptyingcan substantially decrease food intake and alter eating patterns