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[1] [2] Strategic timing of tirzepatide administration may help some patients manage common adverse effects, particularly gastrointestinal symptoms that occur during initial treatment and dose escalation

So they took, took a something and pushed on forearms and they measured how much pressure did it take before the perception was pain instead of pressure, how much force did it take before the patient perceived it as pain

If you are significantly lighter or heavier, the per-injection dose should scale accordingly

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These are decisions that have to be made between a patient and their provider, not by a website