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It is not entirely clear how ALLO, which is a positive allosteric modulator of GABAergic neurotransmission, acts to improve memory function in this patient population, but it has been suggested that stress-induced changes in GABA receptor expression levels are likely to play a role in the etiology of depression

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However, higher doses may be appropriate in the acute phase of stabilizing status epilepticus (as discussed above) or for individual patients with refractory seizures