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(CRC Press

While members of this family carry an autosomal dominant APP duplication rearrangement that leads to early-onset familial AD, including pre-symptomatic (do not fulfill yet the diagnostic criteria) and symptomatic (with clinically diagnosed AD) patients, subjects from the same family in which the genetic testing did not show the APP duplication were considered as non-carrier healthy controls

Finally, it is also important to note that vaccinations with AstraZeneca (viral vector, genetically modified virus vaccine) and Pfizer (mRNA vaccine), but not Sinopharm (inactivated virus vaccine), may aggravate the neuropsychiatric symptoms and, in particular, the somatic symptoms of HAMA and HAMD