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Irisin inhibits Smad3 phosphorylation-mediated ferroptosis and fibrosis, leading to significant alleviation of renal tubular cell injury and fibrotic lesions in UUO, as revealed by results [168]

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The transport of heme within phagocytic cells involved the heme-responsive gene-1 ( HRG1) ( SLC48A1 ) transporter, which facilitates the movement of heme from the phagolysosome to the cytoplasm during erythrophagocytosis