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Finally, the results of one randomized controlled trial in 601 patients with common forms of retinitis pigmentosa indicated that supplementation with 400 IU/day of synthetic vitamin E (equivalent to 180 mg/day of RRR --tocopherol) modestly but significantly accelerated the loss of retinal function compared to placebo (123)

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and hence, can displace them with their catechol group, which then attaches with the binuclear copper ions in the catalytic site of tyrosinase 88

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Hochholdinger F, Guo L, Schnable PS (2004) Lateral roots affect the proteome of the primary root of maize (Zea mays L)