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delbrueckii modulate DCs via the aryl hydrocarbon receptor (AhR) by tryptophan metabolites, inducing indoleamine 2,3-dioxygenase (IDO) for Treg differentiation and suppress autoreactive T-cells (104106) ( Table 2 )

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Its chemical scaffold, particularly the 3,4-dihydroxy arrangement and conjugated double bond, enhances antioxidant capacity yet inherently restricts solubility and absorption (Ren et al., 2024)

Effective clinical management of PASC is contingent upon the following critical evaluation of dysbiosis: (i) the duration of gut dysbiosis after COVID recovery, (ii) the link between gut dysbiosis and long-term persistent symptoms, and (iii) the possible adverse health effects from enriched or depleted specific gut microflora on COVID-19 recovered individuals 254

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