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Formation of sprouts involves (a) Tip cell selection: a cell from the parent vessel becomes the migratory leading cell and blocks its neighboring cells from adopting a tip cell fate by a lateral inhibition process

There are several classes of growth factors that act within the brain by binding to tyrosine kinase receptors including hepatocyte growth factor ( HGF ) and prototypical neurotrophins such as nerve growth factor and brain-derived growth factor 17

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