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Common ones include: Nausea, vomiting, diarrhea and bloating Constipation, which can lead to complications, if not managed Loss of muscle mass, slowing metabolism and making weight maintenance harder Weight cycling, where stopping the medication causes rapid weight gain Among these, chronic constipation is a persistent issue

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The proposed mechanisms are multi-faceted, likely involving anti-inflammatory actions, stabilization of the gut-vascular axis, and promotion of epithelial repair