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In CKD, circulating levels of both Wnt--catenin inhibitors have generally been found to be increased (56), and serum sclerostin was found to correlate negatively with serum PTH (225,226), and PTH has been shown to blunt osteocytic production of this Wnt inhibitor (227)

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Neither peptide is FDA-approved for human therapeutic use

Older adults and adults with gastrointestinal issues may be affected by B12 deficiency as well

PRP delivers autologous growth factors (PDGF, TGF-beta) directly to injury sites and has FDA approval with established safety profiles, though clinical efficacy remains inconsistent across randomized controlled trials