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The ruthenium(II)arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53JNK pathways

Depletion of Glutathione: Several factors can lead to a depletion of glutathione levels in the body: 1

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In response to GSTP1 overexpression-induced cisplatin resistance, a trans-Pt IV carboxylate complex, ethacraplatin (EA-CPT), containing ethacrynate was developed (Figure 6C) [158]