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HR, 0.78), with and without HF (HR, 0.75 vs

9: e108210e108210

For long-term treatment, the maintenance dose may be further increased, with some individuals requiring up to 2 mg once weekly

In patients with renal dysfunction, refractory hypotension, severe metabolic abnormalities, active seizure, or persistent coma, extracorporeal removal by haemodialysis or haemofiltration may be considered, although there are no controlled trials that demonstrate an improvement in outcome with these measures [8890]

No inflammatory signs, degenerative or fibrotic areas were found in any of the experimental group animals, either in the acinar components or in the pancreatic islets (Fig