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Conventional Treatments If the response to conventional treatments is poor or to boost local effect, intratympanic injection (injecting through the eardrum into the middle ear) is used

and caveolin-1 (CAV1), a scaffold protein of caveolar membranes involved in signal transduction and in the uptake of lipophilic compounds, which directly interacts with NRF2, probably competing with KEAP1 for binding to NRF2, and subsequently suppresses its transcriptional activity [231]

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Episode 127: Dr