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Each of these substances is fat-soluble and, unlike water-soluble vitamins, accumulates rapidly in the body, particularly in the adipose tissue and liver

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Further, we showed that deficiency of UCP2 in mouse mast cells decreased the release of inflammatory mediators such as IL-6, PGD 2 , and histamine with inhibition of MAPKs activation (Tagen et al., 2009)

460 Astrocytes may contribute to the pathophysiology of schizophrenia through an increased production of NMDA receptor blocker kynurenic acid, which may also link risk of schizophrenia with infection as described in the previous chapter