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It happens when a bacteria evolves to become strong enough to survive antibiotic treatment, and is caused by exposure to low amounts of the drugs over long periods of time

The pro-inflammatory effects of smoking likely contribute to this accelerated progression of liver damage in the context of viral hepatitis

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When the immune and inflammatory response persists, resulting in the release of cytokines in the inflamed tissue, it gives rise to auto-inflammatory diseases that ultimately lead to cell death

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