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[ Levy DT, Mumford EA, Cummings KM, Gilpin EA, Giovino G, Hyland A, sweanor D, Warner KE: The relative risks of a low-nitrosamine smokeless tobacco product compared with smoking cigarettes: estimates of a panel of experts

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From literature review, although cardiovascular risk is reduced in smokers of low-tar or low-nicotine cigarettes or by reducing the number of cigarettes, the estimated reductions in risk are much less than the increase in risk associated with cigarette smoking when compared to never-smoked individuals

Acting as a depressant, it slows down the brain activity of the user

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