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The researchers also checked for the compounds acetoin and 2,3-pentanedione, which are used as substitutes to diacetyl and may present a respiratory hazard to workers, according to the Flavor and Extract Manufacturers Association

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Smoking cigarettes causes around 78,000 deaths per year in the UK and over 7 million deaths per year worldwide - it is the leading cause of preventable death in the world

To date, our study stands as the only large-scale investigation demonstrating a robust association between smoking and ALD