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The use of contracts to set terms on prices, output, and other conditions has been a growing trend throughout agriculture, but contracts were not widely used for peanuts and tobacco until the 2000s because the marketing quota system and other institutions (e.g., tobacco auctions and farmer cooperatives) served a similar purpose

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Per the applicant, daratumamab binds to the CD38 protein on the surface of the malignant plasma cells which are responsible for abnormal amyloid protein production in AL amyloidosis, directly killing the malignant CD38+ plasma cells and/or directing the immune system to destroy them