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Common side effects The common mild side effects occur in 5% or more of people taking Zepbound: nausea and vomiting constipation or diarrhea burping and gas abdominal pain heartburn or indigestion (upset stomach) hair loss fatigue (low energy) injection site reactions, such as a skin rash, bruising, or itching These side effects are typically temporary and go away within a few days to weeks

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Many patients taking tirzepatide for diabetes or obesity have cardiovascular comorbidities requiring antiplatelet therapy (aspirin, clopidogrel) or anticoagulation (warfarin, direct oral anticoagulants)

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