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Introduction In 2009, approximately 20% (~60 million) of Americans smoked and about ~88 million non-smokers were exposed to secondhand smoke ( Nicotinic acetylcholine receptors (nAChRs) are a family of ionotropic receptor proteins formed by five homologous or identical subunits and are involved in signal transduction between neurons and muscle cells ( NAFLD Is Highly Prevalent in Obese Individuals and Can Be Exaggerated by Smoking Non-alcoholic fatty liver disease is the most common liver disorder and is associated with metabolic syndrome and diabetes mellitus