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Since I was a teenager, with no automobile and a couple hundred bucks in my bank account from a summer job as a Little League umpire, the cigarettes were the obvious choice

A key factor shaping this market is its position as an alternative to traditional cigarettes, with some consumers perceiving smokeless tobacco as a less harmful substitute, particularly in regions with increasing public smoking bans and growing health awareness regarding combustible products

Acknowledgments The authors are thankful to the Director, CSIR-National Botanical Research Institute, Lucknow, for the facilities, and to the Indian Council of Medical Research, New Delhi, for a fellowship to K

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In total, smoking kills more than 480,000 Americans each year, including harm from secondary smoke