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On the other hand, two independent pharmacogenetic studies in patients with moderate-to-severe COPD showed that the therapeutic response and the tolerance to long-term treatment with formoterol (alone or in combination with budesonide) were not modified by the genotype of Arg16Gly 166
95%CI = 1.001.17 per 10 g/m 3 increase in PM 2.5 and NO 2 , respectively) stated in the utmost new meta-analysis (136)
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Nicotine as a chemical has a vasoconstrictor effect, which can reduce blood flow to vital organs
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