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E-cigarettes and asthma Chronic inflammation and airway hyperresponsiveness are key pathophysiological features of bronchial asthma, characterized by increased reactivity of the airways to non-specific stimuli, leading to airway smooth muscle contraction, increased airway resistance, and airflow limitation [65]

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This domain was rated as high risk of bias because the CVD outcomes were assessed through self-reported questionnaires, which may not represent a confirmed CVD diagnosis, given the limitations associated with self-reported data