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This approach is based on three important questions that can be answered prior to cMRTP market introduction using a combination of non-clinical and clinical studies (Fig

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Therefore, we also reported the Akaike Information Criterion (AIC), 54 the BrowneCudeck Criterion (BCC), 55 and the Expected Cross-Validation Index (ECVI), 55 which are the most suited for comparison of nonnested models