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Another study showed that eight months of mice exposure to IQOS did not induce atherosclerotic progression (aortic plaque formation), altered lipid profiles, upper airway epithelial hyperplasia and metaplasia, lung inflammation, and progressive emphysematous changes as CS exposure did

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[55] However, restrictions did have an effect on adult quit rates, with its use declining to the point that by 2004, nearly half of all Americans who had ever smoked had quit