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This is why starting with a very low dose is non-negotiable for beginners

Thus, the patient should be advised to avoid meals or drinks (except water) during or in the 15 minutes preceding oral nicotine use

The addictive nature of nicotine can lead to increased tolerance and potentially pave the way for experimenting with other substances

This is because, in addition to the harmful effects of nicotine itself, tobacco products contain thousands of chemicals, many of which are known or suspected carcinogens

6 Frank Zappa Didnt Tolerate Drugs In His Band Although some in the Mothers of Invention used cannabis, like bassist Tom Fowler who never quit smoking it, Zappa would fire any musician working for him if he found them using speed, heroin, or cocaine